Research

Primary Research Interests:

Circadian Clock

  •  Cryptochrome and Light-Oxygen-Voltage domain proteins
  •  Circadian clock regulatory elements

Bacterial Chemotaxis

  •  Bacterial chemotactic signaling
  • Chemoreceptors and Flagellar motor proteins

Nitric Oxide Synthase

  • Bacterial nitric oxide synthases

Long-range protein electron transfer

  • How does structure and redox-active relay residues control electron transfer
  • Cytochrome c Peroxidase:Cytochrome c complex

We use an assortment of biophysical and biochemical methods to assess these systems, including analytical HPLC, cryo-electron microscopy, electrochemistry, electron spin resonance spectroscopy, genetic and chemical manipulation of proteins, macromolecular crystallography, protein mass spectrometry, radioactivity assays, small-angle X-ray scattering, stopped-flow, and transient absorption spectroscopy, among others.