Research
Primary Research Interests:
Circadian Clock
- Cryptochrome and Light-Oxygen-Voltage domain proteins
- Circadian clock regulatory elements
Bacterial Chemotaxis
- Bacterial chemotactic signaling
- Chemoreceptors and Flagellar motor proteins
Nitric Oxide Synthase
- Bacterial nitric oxide synthases
Long-range protein electron transfer
- How does structure and redox-active relay residues control electron transfer
- Cytochrome c Peroxidase:Cytochrome c complex
We use an assortment of biophysical and biochemical methods to assess these systems, including analytical HPLC, cryo-electron microscopy, electrochemistry, electron spin resonance spectroscopy, genetic and chemical manipulation of proteins, macromolecular crystallography, protein mass spectrometry, radioactivity assays, small-angle X-ray scattering, stopped-flow, and transient absorption spectroscopy, among others.